1. Our laboratory is interested in the function and regulation of tumor suppressor proteins p53 and the retinoblastoma protein (RB) in response to a variety of extracellular signals with an emphasis on breast cancer and lung cancer.


  2. We are interested in developing the physical model and the sampling methodology for drug design. Especially, we will strive for accurate protein-ligand scoring, docking, and protein design methods. We hope to take these methods as powerful tools for Translational Medicine research.


  3. We are interested in using the tools of structural biology, such as X-ray crystallography to investigate the cellular machinery responsible for tumor related protein-protein, protein-ligand interactions.