Ying Tong, PhD.


Associate Professor



Contact: 028-85418843    tongying@scu.edu.cn

Research interests:

    MicroRNAs (miRNAs) are a class of endogenous small non-coding RNAs found in plants and animals, which can 
    post-transcriptionally regulate gene expression, and play key roles in the regulation of a variety of 
    cellular processes and diseases. Their deregulation can lead to cancer development and metastatic 
    evolution. We are screening for miRNAs targeting p53 family members which function as key regulators of 
    cancer progress. We’ve got some candidate miRNAs which can repress the expression of p63/p73 and will 
    further explore their roles in tumorigenesis and metastasis.
    
    The retinoblastoma (RB) gene is the first identified tumor suppressor gene that plays an important role in 
    cell cycle arrest, chromosomal stability, senescence and apoptosis. Pin1, a prolyl cis⁄trans isomerase, 
    can catalyze specific phosphorylated Ser/Thr-Pro isomerization and is essential for cell cycle 
    progression. We have found that Pin1 can directly bind to Rb and repress its activation. We are searching 
    for the mechanisms by which the Pin1-Rb pathway participates in the breast cancer progress.


Bibliography	

    Heng MY, Lin ST, Verret L, Huang Y, Kamiya S, Padiath QS, Tong Y, Palop JJ, Huang EJ, Ptáček LJ, Fu YH. 
    Lamin B1 mediates cell-autonomous neuropathology in a leukodystrophy mouse model. J Clin Invest., 123
    (6):2719-29. 2013.
    Zhou R, Niwa S, Guillaud L, Tong Y, Hirokawa N. A Molecular Motor, KIF13A, Controls Anxiety by 
    Transporting the Serotonin Type 1A Receptor. Cell Reports. 3(2), 509-519. 2013.
    Dahal GR, Rawson J, Gassaway B, Kwok B, Tong Y, Ptácek LJ and Bates E. An inwardly rectifying K+ channel 
    is required for patterning. Development. 139(19), 3653-3664. 2012.
    Tong Y, Xu Y, Scearce-Levie K, Ptacek LJ  and Fu YH. COL25A1 triggers and promotes Alzheimer’s disease-
    like pathology in vivo. Neurogenetics. 11(1):41-52. 2010.